Yaowaluck Maprang Roshom
Clininal Medicine (Immunology), Ph.D.
Email: yaowaluck.ros@kmutt.ac.th
Phone: (+66)2-470-7588 Office: RD1-A3-13, PDTI
Curriculum Vitae

Research Group

Research focus: (Vaccine Development)

Porcine Reproductive and Respiratory Syndrome (PRRS) and Porcine Epidemic Diarrhea (PED) caused by PRRS virus (PRRSV) and PED virus (PEDV), respectively, are currently the most economically important diseases in swine industry worldwide as well as in Thailand. Therefore, a safe and effective vaccine is greatly needed to control the diseases.

Our current research is focused on development of PRRSV and PEDV vaccine candidates that can induce humoral response and cell-mediated response against PRRSV and PEDV. The new antigens are designed based on the genetic codes of PRRSV and PEDV variants currently circulating in Thailand. The new vaccines are developed based on DNA vaccine and viral-based vaccine technology. For viral-based vaccines, repilcation-defective adenovirus and Modified Vaccinia virus Ankara (MVA), whose safety profiles have been confirmed in humans and animals, are employed as vaccine delivery vehicles.

Additionally, we also aim to apply bioinformatics knowledge and tools to help design a novel vaccine antigen carrying highest capacity at inducing both humoral and cell-mediated immunity that can provide protection against PRRSV and PEDV infection.

Selected publications:

  1. Roshorm Y, Cottingham MG, Potash MJ, Volsky DJ, Hanke T. T cells induced by recombinant chimpanzee adenovirus alone and in prime-boost regimens decrease chimeric EcoHIV/NDK challenge virus load. Eur J Immunol. 2012 Dec;42(12):3243-55.
  2. Roshorm Y, Hong JP, Kobayashi N, McMichael AJ, Volsky DJ, Potash MJ, Takiguchi M, Hanke T. Novel HIV-1 clade B candidate vaccines designed for HLA-B*5101(+) patients protected mice against chimaeric ecotropic HIV-1 challenge. Eur J Immunol 2009;39:1831-40.
  3. Im EJ, Hong JP, Roshorm Y, Bridgeman A, Létourneau S, Liljeström P, Potash MJ, Volsky DJ, McMichael AJ, Hanke T. Protective efficacy of serially up-ranked subdominant CD8+ T cell epitopes against virus challenges. PLoS Pathog. 2011 May;7(5):e1002041.
  4. Bridgeman A, Roshorm Y, Lockett LJ, Xu ZZ, Hopkins R, Shaw J, Both GW, Hanke T.Vaccine. Ovine atadenovirus, a novel and highly immunogenic vector in prime-boost studies of a candidate HIV-1 vaccine. 2009 Dec 11;28(2):474-83.
  5. Tirasophon W, Roshorm Y and Panyim S. Silencing of Yellow Head Virus Replication in Penaeid Shrimp Cells by dsRNA. Biochemical and Biophysical Research Communications, 2005 Aug 19;334(1):102-7